MEPSEVII™ (vestronidase alfa-vjbk) should be administered under the supervision of a health care professional with the capability to manage anaphylaxis

 

MEPSEVII recommended dosage overview

  • Approximately 4-hour intravenous drip
  • Administer by intravenous infusion every 2 weeks
  • Infuse 2.5% of the total volume over the first hour
  • After the first hour, increase the infusion rate as tolerated in order to complete infusion over the following 3 hours
  • Premedication with a nonsedating antihistamine with or without an antipyretic is recommended 30 to 60 minutes prior to the start of infusion, for patient comfort

 

Supplies needed

  • MEPSEVII (vestronidase alfa-vjbk) 10-mg/5-mL single-dose vials
  • 0.9% Sodium Chloride Injection, USP
  • Infusion bag
  • 18-gauge needle
  • An infusion set equipped with an in-line, low-protein binding 0.2-micron filter
Image
 

MEPSEVII™ (vestronidase alfa-vjbk) should be administered under the supervision of a health care professional with the capability to manage anaphylaxis


MEPSEVII recommended dosage overview

  • Approximately 4-hour intravenous drip

  • Administer by intravenous infusion every 2 weeks

  • Infuse 2.5% of the total volume over the first hour

  • After the first hour, increase the infusion rate as tolerated in order to complete infusion over the following 3 hours

  • Premedication with a nonsedating antihistamine with or without an antipyretic is recommended 30 to 60 minutes prior to the start of infusion, for patient comfort

Supplies needed

  • MEPSEVII (vestronidase alfa-vjbk) 10-mg/5-mL single-dose vials

  • 0.9% Sodium Chloride Injection, USP

  • Infusion bag

  • 18-gauge needle

  • An infusion set equipped with an in-line, low-protein binding 0.2-micron filter
Image

Calculating the dose

  • Weigh the patient to determine the number of vials to be diluted based on the patient’s actual weight and the recommended dose of 4 mg/kg

  • Round to the next whole vial to determine the final total volume and number of vials needed based on the patient's weight

  • The final solution will be a 1:1 dilution of MEPSEVII with 0.9% Sodium Chloride Injection, USP
Image
 

Calculating the dose

  • Weigh the patient to determine the number of vials to be diluted based on the patient’s actual weight and the recommended dose of 4 mg/kg

  • Round to the next whole vial to determine the final total volume and number of vials needed based on the patient's weight

  • The final solution will be a 1:1 dilution of MEPSEVII with 0.9% Sodium Chloride Injection, USP
Image